- A succeeding model of E2N/E2NS (1996)
- Effective aperture control f/4.8 to 38
- 2/3-in. 1.4-MP CCD (image size: 1,280 x 1,000 pixels)
- Anti-vibration mode for microscope photography
- SCSI interface
- 1 fps (E3)/3 fps (E3S: up to 12 consecutive shots)
- External sync terminal (JIS-B/ISO519-type)